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In studies with healthy volunteers of single doses up to 800 mg, adverse reactions were similar to those seen at lower doses but incidence rates and severities were increased. Analysis of the safety database from controlled clinical trials showed no apparent difference in adverse reactions in patients taking VIAGRA with and without anti-hypertensive medication. This analysis was performed retrospectively, and was not powered to detect any pre-specified difference in adverse reactions. Counseling of patients about the protective measures necessary to guard against sexually transmitted diseases, including the Human Immunodeficiency Virus (HIV), may be considered. However, there are no controlled clinical data on the safety or efficacy of VIAGRA in patients with sickle cell or related anemias. For example, a study conducted at McMaster University examined the effect of sildenafil on erectile function in men with diabetes mellitus.
One of these chemicals, called cyclic GMP, relaxes and widens certain blood vessels in your penis. Cyclic GMP also relaxes the muscles around the erectile tissue in your penis that’s called the corpus cavernosum. These actions allow blood to flow into the corpus cavernosum, which causes your penis to get hard and become erect. This means that if you’re aroused, you should still be able to get an erection up to 4 hours after taking a dose of Viagra. Regardless of your age, you’ll take your prescribed dose about an hour before sex.
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