These carbonyl and hydroxyl oxygens have been proposed to facilitate the switch of the methyl group during catalysis sixteen , 21 , 24 As well as, tyrosine residues within the lysine-binding clefts of SET7/9 (Tyr245 and Tyr305) and solicitor uk DIM-5 (Tyr178) hydrogen-bond to the lysine ε-amino group, aligning it for a methyltransfer with AdoMet (Figure 4b,c ).
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